I like this advice from Josh Catone “Twelve ways to get the most out of Twitter – read more on Sitepoint
1. Form Groups
2. Find the Latest News
3. Share Pictures, Music, and Videos
4. Research Trends
5. Don’t Forget Anything
6. Find People
7. Join a Meme
8. Tweet from the Desktop
9. Follow the Conversation
10. Measure Your Addiction
11. Get SMS Tweeting Back
12. Make Some Money
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Be Human. It is that simple.